Last updated: Friday, 19, November, 2010
Differentiation between intra- and extra-hepatic cholestasis is made by clinical assessment and, as appropriate, diagnostic imaging.
Significant cholestasis may exist without jaundice being apparent.
ALP, GGT, AST, ALT (AST/ALT ratio), LD, bilirubin; PT; FBC.
Liver biopsy, (FNAB), if appropriate.
|See under Pancreatic neoplasm.|
Primary sclerosing cholangitis
Primary biliary cirrhosis
|Mitochondrial antibodies, immunoglobulins G, A, M. Marked elevation of IgM is suggestive of primary biliary cirrhosis.|
Helminth infection, including
|Faeces - ova, cysts and parasites. Identification of fluke found at operation.|
|Fasciola hepatica antibodies are of value for establishing the diagnosis and for monitoring treatment.|
Cholestasis of pregnancy (oestrogen related)
|Liver biopsy; porphyrins - urine.|
|Bile acids - specialised laboratory.|
Hepatocellular disease, especially
|Primary hepatocellular disorders often have a cholestatic component.|