Chronic lymphocytic leukaemia
Last updated: Tuesday, 23, November, 2010
| Consequences | Appropriate Tests |
|---|---|
FBC (lymphocytosis with smudge cells ± anaemia ± neutropenia ± thrombocytopenia); immunophenotyping (blood or bone marrow). Bone marrow aspiration and trephine biopsy are often not required if a clearcut diagnosis is available on immunophenotyping. Immunoglobulins G, A, M; protein electrophoresis - serum with IFE to detect a paraprotein. See Table 2 Reference intervals for immunoglobulins G, A, M (g/L)Cytogenetics (oncology) not required for diagnosis, but may provide information on prognosis. Immunoglobin heavy chain mutation status or Zap-70 assessment have been shown to correlate with clinical outcome; Beta2 microblobulin in serum. Lymph node biopsy is rarely indicated. See Table 1: summary of antigen expression in chronic lymphoproliferative disorders. See also Lymphoproliferative disorders and Chronic leukaemia | |
Immunodeficiency, due to: | Recurrent infection is a common clinical problem. |
| See Humoral immune deficiency under Infection (increased susceptibility). |
| See Cell mediated (T cell) immune dysfunction under Infection (increased susceptibility). |
| Direct antiglobulin test, platetelet antibodies, neutrophil antibodies as appropriate. |
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