Last updated: Wednesday, 24, November, 2010
|Causes + Complications||Appropriate Tests|
The diagnosis is suspected on the basis of clinical assessment and supported by pathology tests.
Although liver biopsy provides the definitive pathological diagnosis, it is not always indicated or feasible.
Liver function can be assessed by albumin, bilirubin, PT.
Ongoing inflammation, necrosis and cholestasis are assessed by AST, ALT (AST/ALT ratio), GGT, ALP, LD, immunoglobulins G, A, M.
Liver function tests may be normal in quiescent cirrhosis.
The findings may be complicated by the coexistence of acute hepatitis and/or hepatic failure.
|Smooth muscle antibodies, liver/kidney microsomal antibodies. See Hepatitis chronic|
|Alpha-1-antitrypsin, with phenotyping, genotyping.|
|See under Glycogen storage diseases.|
|Amino acids - urine, organic acids (succinylacetone).|
Cholestasis (prolonged), especially
Drugs and toxins, including
|In some geographic areas eg, Southeast Asia.|
FBC. Anaemia is often multifactorial: likely cause(s) are indicated by the red cell indices and blood film findings.
Bleeding, due to:
|See Bleeding disorders|
|PT, APTT, fibrinogen. The APTT is less sensitive than the PT to the coagulation factor deficiency of liver disease.|
|See Hepatic failure|
|Usually low grade: thrombin time, fibrinogen, euglobulin clot lysis time. See Fibrinolysis|
|Thrombin time, reptilase time.|
|See Renal failure.|
|See under Alcoholism.|
Portal hypertension, causing
|May be associated Hypersplenism.|