Factor V Leiden mutation
Last updated: Tuesday, 03, August, 2010
|Key Information||Appropriate Tests|
A mutation in the factor V coagulation molecule which renders it resistant to cleavage by activated protein C and leads to a condition referred to as activated protein C resistance.
Testing is indicated in patients who have had venous thromboembolism where investigation for an underlying cause is appropriate (see Thrombosis).
Testing is contoversial and is not considered indicative in asymptomatic individuals unless the defect has been established in a first degree relative.
Activated protein C resistance (screening).
PCR for Factor V Leiden