Haemoglobinuria

Last updated: Friday, 03, December, 2010
CausesAppropriate Tests

Urinalysis (dipstick); this is a reliable test for haemoglobin in urine if properly performed, but does not distinguish haemoglobinuria from haematuria and myoglobinuria.

Urine microscopy to exclude haematuria; haemoglobin - urine, myoglobin - urine (if indicated).

FBC, blood film.

See Haemolysis, Coloured urine, Haematuria, Myoglobinuria

Acute intravascular haemolysis

Haemolytic blood transfusion reaction 

See under Blood transfusion - transfusion reactions.

Cold antibody haemolysis, especially

See under Autoimmune haemolysis

Chronic cold agglutinin disease may present as acute haemolysis with haemoglobinuria.

Acute drug-induced oxidative haemolysis

See under Haemolysis.

Severe burns 

See under Haemolysis.

Clostridium perfringens septicaemia

See under Haemolysis.

Snake bite

See under Haemolysis.

Malaria

See under Haemolysis.

Recurrent or chronic intravascular haemolysis

Microangiopathic haemolysis, especially

  • Cardiac valve haemolysis
  • Haemangioma

Haemosiderin - urine.

Paroxysmal nocturnal haemoglobinuria

See under Autoimmune haemolysis.

Intrinsic red cell defects, especially

 

May be associated with chronic, continuing haemolysis, or acute episodes in association with drugs, intercurrent illness.
See under Haemolysis
See under Sickle cell disorders and Haemolysis.