Heavy chain disease
Last updated: Saturday, 04, December, 2010
| Presentations | Appropriate Tests |
|---|---|
A group of disorders characterised by production of truncated heavy chains of immunoglobulins, without associated light chain production. See also Paraproteinaemia Protein electrophoresis, paraprotein typing. Bone marrow aspiration and trephine biopsy. | |
α Heavy chain disease | |
Malabsorption
| |
γ Heavy chain disease | |
Uvular/palatal oedema | |
Hepatomegaly | |
Lymphadenopathy | |
μ Heavy chain disease | May be associated with Chronic lymphocytic leukaemia. |
Hepatomegaly | |
Splenomegaly |