Heavy chain disease

Last updated: Saturday, 04, December, 2010
PresentationsAppropriate Tests

A group of disorders characterised by production of truncated heavy chains of immunoglobulins, without associated light chain production.

See also Paraproteinaemia

Protein electrophoresis, paraprotein typing. Bone marrow aspiration and trephine biopsy.

α Heavy chain disease

Malabsorption

  • Diarrhoea

γ Heavy chain disease

Uvular/palatal oedema

Hepatomegaly

Lymphadenopathy

μ Heavy chain disease

May be associated with Chronic lymphocytic leukaemia.

Hepatomegaly

Splenomegaly