Hirschsprung's disease

Manifestations	Appropriate Tests
Delayed passage of mecanium	Clinical diagnosis, with diagnostic imaging; diagnosis must be confirmed by colorectal biopsy. Intraoperative frozen section may be considered - consult pathologist. Fresh tissue may be submitted for acetyl cholinesterase immunohistochemistry.
Constipation Abdominal distension
Neuronal intestinal dysplasia - can mimic Hirschsprung's disease

Manifestations

Appropriate Tests

Delayed passage of mecanium

Clinical diagnosis, with diagnostic imaging; diagnosis must be confirmed by colorectal biopsy.

Intraoperative frozen section may be considered - consult pathologist.

Fresh tissue may be submitted for acetyl cholinesterase immunohistochemistry.

Constipation
Abdominal distension

Neuronal intestinal dysplasia - can mimic Hirschsprung's disease

Glossary Terms