Last updated: Friday, 06, August, 2010
|Key Information||Appropriate Tests|
Associations with increased risk of atherothrombotic and venous thromboembolic diseases are recognised.
Serum B12 and red cell folate, Urea and electrolytes and thyroid function.
Methyltetrahydrofolate reductase thermolabile variant (MTHRF C677T mutation);
Homocystinuria (deficiency of cystathione beta-synthase).
Undas et al. Homocysteine and thrombosis: from basic science to clinical evidence, Thrombosis & Haemostasis 2005: 1994; 907-915
Lewis et al. Meta-analysis of MTHFR 6770 - T polymorphism and coronary heart disease: dose totality of evidence support causal role for homocysteine and preventative potential of folate, BMJ 2005; 331: 1053 - 1056