Last updated: Tuesday, 14, December, 2010
CausesAppropriate Tests

The possibility of an underlying cause should be considered. FBC, blood film; creatinine, urea.

Urine urate only occasionally required to distinguish between increased production and decreased renal clearance.

Monitoring should include urate, creatinine, urea.

Increased urate production

Primary metabolic gout

Myeloproliferative disorders

Tumour lysis syndrome, especially

  • Cytotoxic drug therapy

Haemolytic anaemia

See Haemolysis

Type I glycogen storage disease

See under Glycogen storage diseases.

Lesch-Nyhan syndrome


See under Myoglobinuria.
Decreased urate clearance

Renal failure

Pregnancy-induced hypertension (toxaemia)

Urine - protein.

See Hypertension


Drug-induced, especially

  • Thiazides
  • Salicylates



Lactic acidosis

Lead nephropathy

See Lead poisoning