Last updated: Monday, 20, December, 2010
|Key Information||Appropriate Tests|
Review clinical findings, FBC, differential WCC, blood film.
Assessment of lymphocyte morphology assists in determining the aetiology of the lymphocytosis.
If lymphocytosis is persistent (>3 months) and the aetiology is uncertain, immunophenotyping may be useful.
Syndromes characterised by lymphoid cells with atypical morphology (ie activated lymphocytes).
Other infections, especially
Characteristically lymphocytes are morphologically normal or show "reactive features".
Hyposplenism / splenic atrophy or absence.
Associated features of hyposplenism in the peripheral blood film (Howell-Jolly bodies, tareget cells, acanthocytes, thrombocytosis).See Splenic atrophy/absence
Transient lymphocytosis associated with physiological stress
Blood film morphology may be suggestive. Immunophenotyping has a role in sub-typing the lymphoid lineage, confirmation of clonality in B cell disorders and may identify a characteristic immunophenotype in some lymphoproliferative disorders.
Barbara Bain, Blood Cell - A Practical Guide. Third Edition, Blackwell Publishing