Macroglobulinaemia

Last updated: Thursday, 23, December, 2010
Key InformationAppropriate Tests

Paraproteinaemia in which the monoclonal protein is IgM.

Protein (total), albumin; protein electrophoresis, paraprotein typing, immunoglobulins G, A, M; FBC, blood film, differential WCC; ESR.

See also Paraproteinaemia

'Benign' disorders

  • Cold haemagglutinin disease

See Autoimmune haemolysis (idiopathic 'cold' antibody haemolysis).

B lymphoplasmacytic and lymphocytic neoplasms

Bone marrow aspiration and trephine biopsy, lymph node biopsy, as indicated. Lymphocyte immunophenotyping on blood, bone marrow aspirate, lymph node biopsy material, as appropriate.

See also Hyperviscosity syndrome