Pyrexia of unknown origin
Last updated: Friday, 28, January, 2011
PUO is defined as undiagnosed fever of more than 3 weeks duration.
Careful and repeated clinical history and examination; FBC, blood film, differential WCC; CRP ; bilirubin, ALP, AST, ALT, GGT, LD.
Bacterial infection, especially
|Blood culture (repeated); urine microscopy and culture; faeces - microscopy, culture and antigen detection.|
|Urine for mycobacteria testing; collect early morning specimens (three).|
|Cryptococcal antigen - blood, CSF, if appropriate.|
|Malaria parasites - blood - repeated thin and thick blood films, if indicated.|
|FNAB, lesion biopsy; as appropriate. Tumour markers are unreliable as a screening test for occult malignancy.|
Renal cell carcinoma
|See Hepatitis - Granulomatous|
Familial Mediterranean fever
CRP (intermittent elevation); biopsy of appropriate tissue only if clinical features suggest amyloidosis.
Occult haematoma, especially