Waldenstrom macroglobulinaemia (Lymphoplasmacytic Lymphoma)

Last updated: Thursday, 20, January, 2011
PresentationAppropriate Tests

WM is an indolent lymphoid neoplasm, which occurs mainly in older patients.

It is characterised by an IgM paraprotein and a bone marrow infiltrate with monoclonal plasmacytoid lymphocytes.

Hyperviscosity and progressive bone marrow failure are common complications of WM.

FBC, blood film, differential WCC; ESR; bone marrow aspiration/trephine biopsy. Protein (total), albumin, protein electrophoresis, paraprotein quantitation and typing, immunoglobulins G, A, M; plasma viscosity (in advanced disease).

See also Lymphoma, Lymphoproliferative disorders and Paraproteinaemia

Hyperviscosity syndrome

Splenomegaly

Lymphocytosis

Anaemia, neutropenia and thrombocytopenia

Commonly due to bone marrow infiltration.

Bleeding disorders

Paraproteins may inhibit platelet function and/or fibrin polymerisation (thrombin time).

Peripheral neuropathy

See Neuropathy