Parvovirus B19 infection

Last updated: Friday, 24, December, 2010
PresentationsAppropriate Tests

Parvovirus serotype B19 is responsible for clinically significant infections and sequelae - parvovirus B19 antibodies.

Patients with persistent B19 infections may not have antibodies; diagnosis of persistent infection requires virus detection in serum, cells or synovial fluid (research laboratories only).

Erythema infectiosum (Fifth disease) 

Testing usually not necessary.

Subacute polyarthritis

Hydrops fetalis

Pure red cell aplasia 

FBC; bone marrow aspiration may be indicated.

See Aplastic anaemia

Transient aplastic crisis 

In patients with chronic haemolysis eg, sickle cell disorders, hereditary spherocytosis, thalassaemia.

See Haemolysis

Transient erythroblastopenia of childhood

Chronic bone marrow aplasia 

Parvovirus B19 can cause marrow aplasia in patients with immunodeficiency, especially in those with acute leukaemia (lymphoblastic), congenital immunodeficiency states, AIDS and post-organ transplantation.

See Immunodeficiency

FBC; bone marrow aspiration.