Last updated: Thursday, 28, October, 2010
FBC, blood film, reticulocyte count.
Marrow aplasia or hypoplasia is characterised by the finding of pancytopenia.
The diagnosis is established by bone marrow aspirate and matrephine biopsy which are indicated unless the aplasia is a predictable effect of drugs and/or irradiation.
There is broad overlap in pathogenesis, laboratory features and therapy with Paroxysmal Nocturnal Haemoglobinuria (PNH) and hypoplastic MDS.
Agents that commonly cause aplasia in commonly used dosis or normal exposure.
Susceptibility to azathioprine and 6-mercaptopurine is increased in patients with thiopurine methyltransferase deficiency.
Relative low probability in a drug of common use.
Inherited aplestite anaemia. Cytogenetics (non-oncology); molecular genetics.
Association with pure red cell aplasia; see Mediastinal mass.
Linked all-surface proteins.
Flow cytometry assessment of glycophosphatidy inositol (GPI).