Last updated: Friday, 28, January, 2011
Review clinical findings, including history of smoking and diuretic therapy.
Follow up FBC, blood film, red cell mass.
The apparent erythrocytosis is due to reduced plasma volume, eg Dehydration, Diuretic therapy.
Stress polycythaemia (spurious polycythaemia)
Gaisböck syndrome, associated with smoking and alcohol use.
May require measurement of blood volume to exclude absolute erythrocytosis.
Blood volume may be required to document absolute increase in red cell mass. Erythropoietin may be useful: increased levels in secondary erythrocytosis, low to undetectable levels in polycythaemia rubra vera.
Blood gases/haemoximetry. See also Cyanosis.
|See Cystic renal disease|
See under Hypertension.
See under Renal cell mass.
See under Urinary tract obstruction.
Primary haematological disorder
High affinity haemoglobin
Haemoglobin oxygen affinity, Haemoglobin electrophoresis; haemoglobin M.
Review FBC, blood film, red cell mass. Bone marrow aspiration and trephine biopsy may sometimes be useful in documenting other features of a true myeloproliferative disorder.
Presence "invitro" of the formation of spontaneous erythroid colonies (SEC's) in the absence of EPO is a sensitive but not specific finding in PRV.
Low EPO is of high diagnostic specificity for PRV.
Positivity for JAK-2 mutation confirms a myeloproliferative disorder.