Prothrombin gene mutation (G20210A)

Key Information	Appropriate Tests
	Testing is indicated in patients who have had venous thromboembolism where investigation for an underlying cause is appropriate. See Thrombosis and Thrombophilia.
A mutation in the prothrombin molecule (G20210A) which renders it resistant to cleavage by activated protein C resistance. It occurs in ~ 5% of the Australian population in the heterozygous form and is associated with an increased risk of venous thromboembolism.	See Prothrombin gene mutation (G20210A) testing.

Key Information

Appropriate Tests

Testing is indicated in patients who have had venous thromboembolism where investigation for an underlying cause is appropriate.

A mutation in the prothrombin molecule (G20210A) which renders it resistant to cleavage by activated protein C resistance.

It occurs in ~ 5% of the Australian population in the heterozygous form and is associated with an increased risk of venous thromboembolism.