Last updated: Saturday, 05, February, 2011
Diagnosis is based on defined clinical and pathological criteria which include positive antinuclear antibodies and/or positive antibodies to double stranded DNA.
Rheumatoid factor and extractable nuclear antigen antibodies (especially the presence of Sm Antibody) assist to differentiate SLE from other systemic rheumatic diseases.
Disease activity may be monitored by FBC, ESR; and in some patients complement components C3 and C4 and levels of double stranded DNA antibodies.
Creatinine, urea, AST, ALT and CRP may assist to define the extent of disease and complications; lupus inhibitor and cardiolipin antibodies may also predict complications of disease.
Arthritis - polyarticular
Skin and mucous membranes
Lupus band test - skin, may be useful to differentiate between discoid and systemic lupus
Renal biopsy, if indicated.
Direct antiglobulin test.
Coagulation factor inhibitor
APTT, PT; coagulation factor inhibitors.
Abortion - habitual
Antiphospholipid antibody syndrome.
Organic brain syndrome
Stroke (cerebral thrombosis)
No pathology test reliably detects risk.
Drug induced lupus, due to