Splenomegaly

Causes	Appropriate Tests
	Review clinical features, including presence of fever, hepatomegaly, lymphadenopathy. Conditions designated * are typically associated with hepatomegaly. FBC, blood film, platelet count, differential WCC. See also Hypersplenism and Hepatomegaly
Infections
Viral, especially Infectious mononucleosis* Cytomegalovirus infection HIV infection
Bacterial, especially Endocarditis Septicaemia Typhoid
Parasitic, especially Malaria* Leishmaniasis* Schistosomiasis
Immune disorders SLE Felty syndrome
Disordered splenic blood flow Portal hypertension* Haemolytic anaemia Autoimmune haemolysis* Hereditary spherocytosis Homozygous b thalassaemia* Haemoglobin H disease*	See under Thalassaemia See under Thalassaemia
Infiltrative* Myeloproliferative disorders* Lymphoma* Chronic lymphocytic leukaemia* Hairy cell leukaemia Prolymphocytic leukaemia Amyloidosis* Lysosomal storage diseases*

Glossary Terms