Thrombocythaemia (essential)
Last updated: Saturday, 15, January, 2011
| Presentation | Appropriate Tests |
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Essential thrombocythaemia is a myeloproliferative disorder in which the haemopoietic stem cell proliferation leads to a predominant increase in platelet numbers, usually with neutrophilia. FBC, blood film; bone marrow aspiration and trephine biopsy. JAK-2 mutation may be positive in 50% pts with ET. See also Myeloproliferative disorders | |
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Thrombosis (arterial or venous) | . |
Bleeding | May be from a local lesion. |
Platelet dysfunction | Variable abnormalities of platelet function have been described. The bleeding time does not predict spontaneous or surgical bleeding and is not indicated. |
Acquired von Willebrand's disease | |
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Anaemia, especially | |
Disease progression/transformation to |