Last updated: Friday, 21, January, 2011
Review clinical features, including distribution of sensory and/or motor abnormalities: it is important to distinguish peripheral neuropathy from spinal cord disease eg, subacute combined degeneration of the cord, tabes dorsalis.
Pathology tests may assist in defining underlying disorders.
Nerve biopsy if diagnosis uncertain, or confirmation required.
Systemic necrotising vasculitis
|See under Vasculitis|
Cerebrospinal fluid examination - microscopy, protein, protein electrophoresis.
There is characteristically a marked increase in CSF protein, with oligoclonal bands and a normal, or only slightly increased, CSF cell count.
Chronic inflammatory demyelinating polyneuropathy
Systemic disease, especially
Associated with neoplasia, including
Phytanate - plasma or serum.