Hepatitis B virus (HBV) testing - serum
Last updated: Sunday, 21, May, 2006
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|Specimen||5-10 mL blood in plain tube.|
Acute or chronic hepatitis;
HBeAg should only be requested if it is known that HBsAg is positive.
HBV DNA-p and HBV DNA are only available from specialised laboratories and their use is restricted.
Positive HBsAg indicates acute HBV infection or carrier status and implies infectivity.
Positive anti-HBs indicates immunity to HBV.
Positive anti-HBc IgM indicates recent infection; anti-HBc IgG indicates past infection or HBV carrier status; the significance depends on results for HBsAg and anti-HBs.
The detection of HBeAg in HBsAg positive patients indicates greater infectivity and its persistence indicates an increased risk of chronic liver disease (chronic hepatitis, cirrhosis, hepatocellular carcinoma).
Positive anti-HBe is associated with a better prognosis and less infectivity.
HBV DNA-p and HBV DNA in serum or liver are markers for viral replication.
Hoofnagle JH and Di Bisceglie AM. Semin Liver Dis 1991; 11: 73-83.
Koziel MJ and Siddiqui A. In: Mandell GR et al eds. Principles and Practice of Infectious Diseases. 6th ed. Churchill Livingstone 2005.