Cytomegalovirus (CMV) antibodies - serum
Last updated: Sunday, 21, May, 2006
MBS Online Search Page: Click here for details
5-10 mL blood. Acute and convalescent (2 weeks) specimens are required.
EIA, IHA, IF.
| Reference Interval|
Mononucleosis syndrome (with negative Epstein-Barr virus serology); acute hepatitis (after exclusion of HAV, HBV, HCV infection); possible congenital CMV infection;
IgG seroconversion from negative to positive is a reliable indicator of primary infection.
A stable positive result for total or IgG antibodies indicates past infection.
A 4-fold or greater rise in IgG usually represents recent infection, often due to reactivation or reinfection. However, this should be confirmed by viral detection, since 4-fold fluctuations in titre may occur in healthy individuals.
Detection of IgM antibody can indicate recent infection but is not always a reliable indicator as IgM can persist for long periods.
IgG avidity determination may be used if diagnosis of acute primary infection is critical eg in early pregnancy.
In a neonate, the presence of IgM indicates intrauterine infection.
Revello MG and Gerna G. Clin Microbiol Rev 2002; 15: 680-715.