Cryptococcal antigen - serum, CSF
Last updated: Saturday, 03, April, 2004
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5-10 mL blood or 2 mL CSF in plain tube.
Diagnosis of cryptococcal infection; monitoring response to therapy.
Positive in both serum and CSF in >95% of patients with cryptococcal meningitis; a negative result does not exclude infection.
Antigen levels decrease with effective therapy, but there is a poor correlation between antigen levels and disease activity in HIV positive patients.
Mitchell T and Perfect J. Clin Microbiol Rev 1995; 8: 515-548.