Chlamydia antibodies - serum

Last updated: Wednesday, 20, June, 2007

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Item Process
Specimen

5-10 mL blood in plain tube.

Acute and convalescent (2-6 weeks) samples are required.

Method

CFT, IF, EIA.

Application

Atypical pneumonia, pneumonia in the first 6 months of life.

Lymphogranuloma venereum (LGV).

Assessment of infertility.

Interpretation

Interpretation depends on the clinical context.

Tests detect antibodies against a group antigen (LGV-1) shared by Chlamydophila psittaci and Chlamydia trachomatis.

A four-fold rise in IgG, or the presence of IgM, indicates recent psittacosis or lymphogranuloma venereum.

Chlamydia antibodies are not useful for the diagnosis current of genital tract infection or trachoma caused by non-LGV-1 strains of C. trachomatis.

The presence of IgM antibodies supports the diagnosis of C. trachomatis pneumonia in neonates although negative results do not exclude the possibility.

See also Genital swab.

Reference

Hammerschlag MR. Clin Microbiol Newslett 2001; 23: 107 - 111.