Extractable nuclear antigen (ENA) antibodies - serum
Last updated: Friday, 14, August, 2009
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5 mL blood in plain tube.
| Reference Interval|
Performed when the ANA is positive to determine ANA specificities, some of which identify categories of disease with implications important for treatment and prognosis.
Also indicated when there is a high suspicion of connective tissue disease with negative ANA; antibodies to Ro (SS-A) may not be detected by ANA.
The presence of antibodies against extractable nuclear antigen is highly suggestive of systemic rheumatic disease.
Defined antigen specificities include:
Tan EM et al. Clin Immunol Immunopath 1988; 47: 121-141.
Phan T et al. Clinical and Diagnostic Laboratory Immunology Jan 2002: 1 - 7.