Lung biopsy

Last updated: Monday, 05, April, 2004

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Item Process
Specimen

Fine needle aspiration biopsy, bronchial/transbronchial, transthoracic needle biopsy, open lung, lobectomy and pneumonectomy specimens. 

Specimens requiring culture should be submitted fresh, as should larger specimens requiring fixation by inflation.

Method

Fresh tissue: frozen section, microbiological examination, (bacterial, fungal and myobacterial microscopy and culture if indicated) molecular genetics.

Fixed tissue: light microscopy, immunohistochemistry, electron microscopy (special fixative).

Application

May be indicated in the investigation of: pneumonias (infective and non-infective), allergic and granulomatous disease, pulmonary fibrosis, pulmonary hypertension, vasculitis, pneumoconiosis and tumours.

Interpretation

Categorisation and prognosis of alveolar and interstitial pneumonias;
identification of infecting organisms;
typing of granulomatous disease including sarcoid;
diagnosis of primary and systemic vascular disorders;
typing of pneumoconiosis and identification of complications; and
identification of tumour type, grade and stage.

Reference

Fraser RS et al. Diagnosis of Diseases of the Chest. Saunders 2000.