Jo-1 antibodies (Histidyl-tRNA synthetase antibodies) - serum

Last updated: Wednesday, 17, March, 2004

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Item Process
Specimen

5 mL blood in plain tube.

Method

Immunoassay.

Reference Interval

Qualitative test.

Application

Diagnosis of polymyositis.

Interpretation

The presence of Jo-1 antibodies defines a subset of polymyositis with associated interstitial lung disease. It is present in a small proportion of patients with polymyositis alone.

Autoantibodies against other t-RNA synthetases are also found in association with polymyositis.

Reference

Imbert-Masseau A. Joint Bone Spine 2003; 70(3): 161-168.