Oesophageal brushing cytology

Last updated: Monday, 05, April, 2004

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Item Process
Specimen

Directional reusable brush samples may be collected and rolled directly onto the surface of glass slides for immediate fixation in alcohol or, less commonly, air-drying and post-fixation in methanol. 

Disposable brush sample tips may be cut off into thin layer preparation solution if this technique is available. 

Brush samples should be taken prior to biopsies to reduce blood contamination.

Application

Investigation of endoscopically identified inflammatory conditions, epithelial tumours and non-epithelial tumours.

Interpretation

Comments provided by a pathologist on the presence or absence of malignancy.

Highly sensitive technique for identifying Candida infection. 

May also reliably identify Herpes simplex ulceration and Cytomegalovirus (CMV) infection.

Reference

Deere A. In: Gray W and McKee GT eds. Diagnostic Cytopathology. 2nd ed. Churchill Livingstone 2003.