Last updated: Monday, 06, August, 2007
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|Specimen||4.5 mL blood added to 0.5 mL citrate.|
|Method||Clot solubility test.|
| Reference Interval||Qualitative test which detects major deficiencies of Factor XIII.|
Investigation of patients with a personal and/or family history suggestive of an inherited bleeding disorder.
Factor XIII (fibrin stabilising factor) deficiency is rare.
In the presence of factor XIII, fibrin is stabilised by transglutaminase-mediated peptide bonds and the clot is insoluble in eg, strong urea.
In patients with factor XIII deficiency, cross-linking of fibrin is deficient and the clot dissolves. The sensitivity of this test is low - consult pathologist.
|Reference||Dacie JV and Lewis SM. Practical Haematology. 8th ed. Churchill Livingstone 1995.|