Factor XIII

Last updated: Monday, 06, August, 2007

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Item Process
Specimen4.5 mL blood added to 0.5 mL citrate.
MethodClot solubility test.
Reference Interval
Qualitative test which detects major deficiencies of Factor XIII.
Application

Investigation of patients with a personal and/or family history suggestive of an inherited bleeding disorder.

Factor XIII (fibrin stabilising factor) deficiency is rare.

Interpretation

In the presence of factor XIII, fibrin is stabilised by transglutaminase-mediated peptide bonds and the clot is insoluble in eg, strong urea.

In patients with factor XIII deficiency, cross-linking of fibrin is deficient and the clot dissolves. The sensitivity of this test is low - consult pathologist.

ReferenceDacie JV and Lewis SM. Practical Haematology. 8th ed. Churchill Livingstone 1995.