Glucose-6-Phosphate Dehydrogenase (G-6-PD) - red cell
Last updated: Wednesday, 05, December, 2007
MBS Online Search Page: Click here for details
5 mL blood in ACD, lithium heparin or EDTA.
Semi-quantitative fluorescence test and methaemoglobin reduction test; enzyme assay.
Molecular genetics techniques are available - consult pathologist.
| Reference Interval|
The G6PD assay reference intervals are:
3.0-4.2 IU/1010 red cells (WHO)
Newborns and infants may have values that deviate from these values by 150%.
Investigation of haemolytic anaemia, particularly when haemolysis is related to ingestion of broad beans, or to the use of oxidant drugs (eg, anti-malarials, sulphonamides).
The specific enzyme assay confirms deficiency.
Low levels indicate red cell G-6-PD deficiency.
Genetic variants occur in different racial groups; clinically significant haemolysis may be seen in patients from the Mediterranean, SE Asia and Africa.
Some G-6-PD deficient individuals have increased susceptibility to oxidant drug haemolysis.
Beutler E. Blood 1994; 84(11): 3613-3636