Haemosiderin - urine

Last updated: Wednesday, 28, April, 2004

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Item Process
Specimen

Fresh, early morning urine sample.

Method

Iron stain of centrifuged deposit of urine.

Microscopic examination for intracellular iron-containing granules.

Reference Interval

Not detected.

Application

Investigation of possible chronic intravascular haemolysis.

Interpretation

Haemoglobin in glomerular filtrate is reabsorbed by renal tubular cells and broken down to haemosiderin.

Presence of haemosiderin in uroepithelial cells indicates chronic intravascular haemolysis.

Reference

Dacie JV and Lewis SM. Practical Haematology. 8th ed. Churchill Livingstone 1995.