Heinz body preparation - blood
Last updated: Friday, 02, April, 2004
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5 mL blood in EDTA.
Fresh blood incubated with supravital stain and examined by microscopy for presence of stained inclusions close to the red cell membrane (Heinz bodies).
| Reference Interval|
Investigation of haemolysis (when fragmented spherocytes seen on blood film) or with history of exposure to oxidant chemical or drug.
Heinz bodies are denatured globin, and represent the end-product of oxidative degradation of haemoglobin.
Heinz bodies may be detected post-splenectomy, with oxidative haemolysis (in normals, but particularly in patients with G-6-PD deficiency) and in patients with unstable haemoglobinopathies.
Dacie JV and Lewis SM. Practical Haematology. 8th ed. Churchill Livingstone 1995.