Neutrophil antibodies
Last updated: Monday, 22, March, 2004
Rarely used and only performed in specialised laboratories.
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| Item | Process |
|---|---|
| Specimen | 5 mL blood in EDTA for 'direct' tests of neutrophil-bound antibody and 10 mL in plain tube for 'indirect' tests of antibody in serum |
| Method | Direct and indirect immunofluoresence. |
| Application | Investigation of neutropenia, when immune-mediated (including drug-induced) neutropenia is suspected. |
| Interpretation | A positive result is seen in immune neutropenia and drug-induced neutropenia eg, secondary to penicillins, cephalosporins, vancomycin. |
| Reference | Dacie JV and Lewis SM. Practical Haematology. 8th ed. Churchill Livingstone 1995. Bux J and Mueller-Eckhardt C. Semin Haematol 1992; 29: 45-63. |