Red cell survival
Last updated: Thursday, 25, March, 2004
Rarely used and probably obsolete.
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In vivo method requires patient to attend at intervals for 1-4 weeks.
Patient’s red cells labelled with radioactive isotope (51Cr) and re-injected.
Samples collected at regular intervals for up to 4 weeks.
| Reference Interval|
Red cell half-life: 25-35 days
Rarely indicated for the documentation of haemolysis.
Occasionally used to test survival of transfused red cells in face of major problems in compatibility testing.
Reduced red cell survival in the absence of blood loss confirms haemolysis.
Surface counting may also be used to indicate the site of red cell destruction (spleen or liver).
ICSH. Br J Haematol 1971; 21: 241-250.