Ristocetin-induced platelet aggregation

Last updated: Friday, 02, April, 2004

MBS Online Search Page: Click here for details

Item Process

5-10 mL blood in citrate (collected by laboratory).


See Platelet aggregation/release.

Reference Interval

Consult laboratory.


Investigation of patients with a history suggestive of an inherited bleeding disorder.


An insensitive test for reduced levels of von Willebrand factor (classical von Willebrand’s disease). However, the test is useful for the detection of variant von Willebrand’s disease (especially Type 2 VWD and pseudo [platelet-type] VWD).

Ristocetin-induced platelet aggregation (RIPA) is absent in Bernard Soulier syndrome, a rare autosomal recessive bleeding disorder. This is due to the absence of the receptor for ristocetin on the platelet surface.


Favaloro EJ. Clin Haematol 2001; 14: 299-319.

Rodeghiero F et al. Thromb Haemost 1990; 64: 349-352.