Last updated: Friday, 02, April, 2004
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4.5 mL blood added to 0.5mL citrate.
Thrombin added to platelet-poor plasma at 37°C; the clotting time is recorded.
| Reference Interval|
Varies with laboratory and method. Typically 14-16 seconds.
Investigation of possible acquired or inherited disorders of haemostasis.
Occasionally indicated in the investigation of unexplained thrombosis.
Prolonged in afibrinogenaemia, hypofibrinogenaemia, dysfibrinogenaemia. Prolonged by heparin (corrects with protamine), FDP, paraproteins (partial correction with protamine).
Chanarin I ed. Laboratory Haematology. Churchill Livingstone 1989.