Thrombin time
Last updated: Friday, 02, April, 2004
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| Item | Process |
|---|---|
| Specimen | 4.5 mL blood added to 0.5mL citrate. |
| Method | Thrombin added to platelet-poor plasma at 37°C; the clotting time is recorded. |
| Reference Interval | Varies with laboratory and method. Typically 14-16 seconds. |
| Application | Investigation of possible acquired or inherited disorders of haemostasis. Occasionally indicated in the investigation of unexplained thrombosis. |
| Interpretation | Prolonged in afibrinogenaemia, hypofibrinogenaemia, dysfibrinogenaemia. Prolonged by heparin (corrects with protamine), FDP, paraproteins (partial correction with protamine). |
| Reference | Chanarin I ed. Laboratory Haematology. Churchill Livingstone 1989. |