Hepatitis C genotyping

Last updated: Tuesday, 23, March, 2004

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Item Process
Specimen

5-10 mL blood in EDTA or citrate.

Method

Detection of subtype specific mutations (various methodologies) after amplification, amplification using subtype specific primers, nucleic acid sequencing of amplified product if required.

Application

Pre-treatment evaluation of patients being considered for antiviral therapy.

Interpretation

Genotyping, together with viral load, is used to determine the appropriate duration of therapy. Infection with genotypes 2 and 3 responds better to antivirals.

Reference

Rosenberg PM. Clin Infect Dis 2001; 33: 1728 -732.