Pemphigus antibodies - serum

Last updated: Wednesday, 11, July, 2007

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Item Process

10 mL blood in plain tube.


Indirect IF, Immunoassay.

Reference Interval

Method dependent.


Diagnosis of bullous skin diseases.

Differentiates pemphigus from pemphigoid.


Intercellular cement substance antibodies (also known as desmoglein antibodies) are specific for pemphigus.

Titres correlate with disease activity and effect of treatment.

Pemphigus-like antibodies occur in burns, drug reactions and other disorders with extensive skin damage.


Stanley J. J Exp Med 1995; 181: 1-4.

Zagorodniuk, I. et al A comparison of anti-desmoglein antibodies and indirect immunofluorescence in the serodiagnosis of pemphigus vulgaris International Journal of Dermatology 2003; 44(7) 541 - 544