Thyroid antibodies – serum

Last updated: Tuesday, 30, March, 2004

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Item Process
Specimen

5 mL blood in plain tube.

Method

Immunoassay for thyroid microsomal/ peroxidase and thyroglobulin antibodies.

Reference Interval

Consult pathologist.

Application

Diagnosis of Hashimoto thyroiditis;
follow up of post-partum or subacute thyroiditis;
investigation of unexplained ophthalmopathy or myopathy.

Interpretation

Positive thyroid microsomal antibodies or thyroglobulin antibodies occur in virtually all patients with Hashimoto disease.

Thyroid microsomal antibodies have greater sensitivity than thyroglobulin antibodies for Hashimoto thyroiditis. However, positive results can occur in patients with other forms of autoimmune thyroid disease and other tissue specific autoimmune disease.

 These antibodies also occur in low titre in up to 20% of the normal elderly population.

Reference

Saravanan P et al. Endocrinol Metab Clin North Am 2001; 30(2): 315-337.