Albumin - urine

Last updated: Wednesday, 07, April, 2004
Item Process
Specimen

Random urine samples are now preferred.

Patients should refrain from vigorous exercise for 24 hours prior to sample collection.

Method

Immunoassay.

Reference Interval

Normal:<30 mg albumin/g creatinine
Microalbuminuria: 30 to 300 mg albumin/g creatinine
Macroalbuminuria: >300 mg albumin/g creatinine.

Application

Early detection of diabetic nephropathy; investigation and monitoring of renal disease.

Interpretation

Increased excretion of albumin (>30 mg/g creatinine) of insufficient degree to be detected by dipstick is an early sign of diabetic nephropathy.

Microalbuminuria (30-300 mg/g creatinine) is an early marker of renal damage that may be progressive if risk factors are not adequately treated.

Urine albumin is elevated in the nephrotic syndrome, in other conditions with increased glomerular permeability (eg, glomerulonephritis), and in urinary tract inflammation. It can be used instead of urinary protein to detect or monitor these conditions.

See also Urinalysis.

Reference

Eknoyan G et al. Am J Kidney Dis 2003; 42(4): 617-622.