Alpha-1-antitrypsin - faeces
Last updated: Wednesday, 07, April, 2004
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Random: 5 g faeces; a test for occult blood in faeces should also be performed to exclude bleeding as a cause of an elevated α1-antitrypsin.
A clearance study requires a three day faecal collection (faeces should be frozen during collection period if possible) plus 5 mL blood in a plain tube for serum α1-antitrypsin assay.
| Reference Interval|
Random: <1.5 mg/g dry weight
Investigation of protein-losing enteropathies.
If α1-antitrypsin is elevated in the absence of a positive occult blood test, increased loss of plasma proteins from the bowel is present. If occult blood is positive, the α1-antitrypsin is at least partly derived from blood loss, but a coexistent protein-losing enteropathy cannot be excluded.
Perlmutter DH. Gastroenterol Clin N Amer 1995; 24: 27-43.