Angiotensin converting enzyme (ACE) - serum

Last updated: Wednesday, 07, April, 2004

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Item Process
Specimen

5 mL blood in plain tube.

Method

Spectrophotometry.

Reference Interval

Method dependent, typically 12-40 U/L.

Application

Limited role in the investigation and monitoring of sarcoidosis.

Interpretation

Increased levels are found in at least 80% of patients with lung or multisystem sarcoidosis, but the test is less sensitive when only one system, other than lung, is involved.

Increased levels are also found in patients with other granulomatous diseases eg, tuberculosis, leprosy, asbestosis and silicosis, and occasionally in those with diabetes mellitus, hyperthyroidism.

Low levels are found in patients taking ACE inhibitors or corticosteroids.

Reference

Muller BR. Ann Clin Biochem 2002; 39: 436-443.