Antidiuretic hormone (ADH) - plasma

Last updated: Wednesday, 07, April, 2004

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Item Process
Specimen

5 mL blood in EDTA tube. The tube should be pre-cooled and delivered to the laboratory on melting ice, for immediate separation at 4°C and freezing.

Method

Immunoassay.

Reference Interval

Depends on plasma osmolality and intravascular volume.

Application

The test may be used, in conjunction with plasma osmolality, to distinguish between central and nephrogenic diabetes insipidus.

Interpretation

Central diabetes insipidus is associated with low ADH levels, regardless of plasma osmolality.

Nephrogenic diabetes inspidus is associated with increasing levels of ADH as plasma osmolality increases.

Reference

Janicic N and Verbalis JG. Metab Clin North Am 2003; 32(2): 459-481.