Chloride - urine

Last updated: Wednesday, 14, April, 2004

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Item Process

Random or 24 hour urine collection without preservative.


Spectrophotometry, coulimetry or ISE.

Reference Interval

Dependent on intake, typically 100-250 mmol/24 hours.


To define the site of chloride loss in metabolic alkalosis and other electrolyte disturbances when it is not obvious clinically. Monitoring compliance with a low salt diet.


Patients with a metabolic alkalosis and an associated urine chloride level of <10 mmol/L are usually chloride deficient from gut or sweat loss and may require replacement therapy.


Harrington JT and Cohen JJ. N Engl J Med 1975; 293(24): 1241-1243.