Clonazepam - plasma or serum

Last updated: Tuesday, 30, March, 2004

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Item Process
Specimen

5 mL blood in lithium heparin or plain tube.

The specimen should be taken at least four hours after the last dose.

Method

HPLC.

Therapeutic Interval

50-160 nmol/L (15-50 µg/L).

Application

Monitoring clonazepam therapy.

Interpretation

The drug has a half-life of approximately 40 hours.

Reference

Nanda RN et al. J Neurol Neurosurg Psychiatry 1977; 40: 538-543.

Epilepsia. 2000; 41:8 6-15. Review.