Copper - urine

Last updated: Thursday, 08, April, 2004

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Item Process
Specimen

24 hour urine collection in a copper-free container.

Method

Atomic absorption spectrophotometry.

Reference Interval

<1.2 µmol/24 hours.

Application

Investigation of disorders of copper metabolism, particularly Wilson’s disease.

Interpretation

High urinary copper is found in Wilson’s disease and other copper toxicity states, eg, Indian childhood cirrhosis.

It is also increased in other diseases affecting copper excretion, eg, primary biliary cirrhosis.

Reference

Ferenci P et al. Liver Int 2003; 23(3): 139-142.