Dehydroepiandrosterone sulphate - plasma or serum

Last updated: Wednesday, 07, April, 2004

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Item Process
Specimen

5 mL blood in a lithium heparin or plain tube.

Method

Immunoassay.

Some laboratories measure DHEA, rather than DHEAS.

Reference Interval

Age dependent.

Adult female, premenopausal: 1-11 µmol/L.

Application

Investigation of infertility, hirsutism, and virilisation in females.

Interpretation

Elevated levels indicate an adrenal origin of androgens, typically congenital adrenal hyperplasia or adrenal tumour.

Slight elevations may be of no clinical significance.

Reference

Siegel SF et al. N Engl J Med 1990; 323(13): 849-854.